The Cardinals, trailing 3-1, struck for two runs in the fifth inning, three in the sixth and three in the seventh to claim the Central Ozark Conference Large Division showdown.
Webb City (6-2, 2-0) finished with 13 hits and three home runs against the Tigers.
Winning pitcher Kaitlin Beason, who yielded seven hits, struck out five and walked one, unloaded a solo homer in the first inning and a two-run blow in the fifth. Megan Heman socked a three-run homer in the sixth to make it 6-3.
Beason and Emily Harris each had three hits for the Cardinals. Heman and Desirea Buerge each had two hits and Mikaela Burgess rapped a two-run double in the seventh.